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There should be an interval of at least 8 hours between successive doses of bupropion.

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bupropion is approved for use as a smoking cessation aid, and more recently has drawn attention as a potential pharmacotherapy for cocaine and methamphetamine abuse.

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those reports and the present findings collectively indicate pharmacological heterogeneity among da reuptake inhibitors and support the idea of the possible existence of at least two distinct classes of da reuptake inhibitors; the self-administration of one class of da reuptake inhibitors cocaine and bupropion leads to up-regulation of da transporters, whereas the self-administration of another class nomifensine and gbr-12909 does not alter transporter levels.

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specifically, on bupropion 10 mg kg intraperitoneal sessions, offset of 15-second cue lights were followed by brief delivery of liquid sucrose; saline sessions were similar except no sucrose was available.

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