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Paroxetine is also available in a controlled release preparation paxil cr , which may improve tolerability, but it still inhibits p450 2d6.
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paroxetine in a study of the interaction between the selective serotonin reuptake inhibitor ssri paroxetine 20 mg day for two weeks and a single dose of maxalt 10 mg in healthy subjects n 12 , neither the plasma concentrations of rizatriptan nor its safety profile were affected by paroxetine see warnings and precautions 5.
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in a separate study, when a single oral 300 mg dose of phenytoin was administered at paroxetine steady state 30 mg once daily for 14 days , phenytoin auc was slightly reduced 12 on average compared to phenytoin administered alone.
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phenytoin – when a single oral 30 mg dose of paroxetine was administered at phenytoin steady state 300 mg qd for 14 days , paroxetine auc and t were reduced by an average of 50 and 35 , respectively compared to paroxetine administered alone.
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